HPLC Solvent Purification

Solvent Filteration and Degassing Products

LAZAR INTRODUCES...
Pure and Simple Solutions to Liquid Chromatography Problems.
HPLC, as an analytical tool for detection and separation of chemical compounds,
has become the most important laboratory technique over the last decade. As
with all analytical techniques, minor processing problems sometimes appear
which in the long run can have major impact on the accuracy of the system as
well as its durability.
Although the evolution of liquid chromatographs has brought the instruments
via the microprocessor into the computer age there are still problems which
the computer cannot solve.
This is why we at LAZAR have spent the majority of our R & D time in solving
those seemingly simple but persistent problems so that we can proudly tell
you that we have the pure and simple chromatography solutions.

VERSATILITY AND FLEXIBILITY
The LAZAR Filter-Degasser can be used to accommodate almost all HPLC
applications. For most ISOCRATIC applications, the Filter-Degasser can be
directly screwed onto the popular 1 liter HPLC solvent/reservoir bottle (38mm
cap). In this fashion, it is not necessary to further transfer the filtered-
degassed solvent where reabsorption of gasses as well as particle contamination
can further occur. 28mm and 33mm caps for 250 and 500 ml bottles are also
available.
The Filter-Degasser with 38mm cap also fits on the standard one gallon (4 liter)
solvent bottle for filtration and degassing of solvent without requiring an
operator's attention. A gallon of solvent can usually be filtered in less than
10 minutes. Further, the Filter-Degasser is also available with 24/40 and 19/22
standard taper for use with various Erlenmeyer and volumetric flasks. In
addition it can be used with a 40/35 standard taper for use with the
Millipore® type filtration flasks.
For most GRADIENT separations, binary or ternary, LAZAR offers a versatile
manifold system where simultaneous vacuum filtration and degassing of 2 or 3
solvents can be run from one vacuum source.
The manifold system features individual shutoff valves for each vacuum
operation, quick disconnect couplings for the individual filtration units,
a master control valve for adjusting vacuum flow, and a disposable vacuum
line filter as a safety feature against pump contaminants.  The manifold
can be attached to any vacuum source.


 All fluoropolymer Filter Degasser

 Chempure All fluoropolymer Filteration System 




ALL fluoropolymer FILTER-DEGASSER -the Simple Approach to Solvent Purification
   
Features
*All PFA fluoropolymer construction- inert to most solvents, aqueous or organic.
*Simple to install- fits directly on your standard solvent bottles or
 Erlenmeyer flasks.
*Simple and economical to use- attach to any available vacuum line, put in
 the filter and you're operational.
*In-line device can filter/degass 1 gallon in less than 10 minutes.
*Vacuum line also establishes siphon to transfer solvent to storage bottle.

Filtration and degassing of solvents and samples prior to analysis is
recommended by most instrument manufacturers. Instrument manufacturers
understand that particulate matter in solvents can cause damage to expensive
pumps, clog analytical columns, and in general cause wear and tear to the
instruments.
The combination of particulate matter and dissolved gasses in solvents can
also create spurious peaks or can result in baseline instability. Dissolved
oxygen in solvents can cause direct interference with fluorescence and
electrochemical detectors. HPLC grade solvents, even though filtered prior to
shipment by the manufacturer, can accumulate particles during storage due to
shedding from the solvent containers and solvent condensation or
polymerization. The use of salts and buffers can also significantly
contribute to particles in the mobile phase.
Filtration and degassing of solvents with the LAZAR Filter/Degasser reduces
instrument down-time, prolongs the life of the analytical columns, pumps,
and valves and most importantly helps the instrument perform in optimal
fashion.

Ordering Information

ITEM				  CATALOG NO.	   DESCRIPTION
Filter Degasser			   FG-256	    with 38 mm cap.
      "				   FG-256-33	    with 33 mm cap.
      "				   FG-256-28	    with 28 mm cap.
      "				   FG-256-24	    with 24/40 std. taper.
      "				   FG-256-22	    with 19/22 std. taper.
      "				   FG-256-35	    with 40/35 std. taper.

Filter Membranes		   SM-256	    fluoropolymer filter membranes
(47 mm dia., 0.2 micro-				    for organic solvents,
meter porosity)					    pkg. of 10.

Filter Membranes		   SM-256A          Hydrophillic filter
(47 mm dia., 0.45 micro-			    membranes for
meter porosity)					    aqueous solvents,
						    pkg. of 10



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CHEMPURE ALL fluoropolymer FILTRATION SYSTEM
  
HIGH PURITY PREPARATION OF SOLVENTS AND SAMPLES.

Features
*All fluoropolymer construction for chemical inertness.
*Versatility and flexibility with adapters to accommodate most solvent
 bottles and Erlenmeyer flasks.
*All fluoropolymer funnel-volume 150 ml is standard with 300 ml optional.
*PFA fluoropolymer screen to hold filter membranes.
*Costs significantly lower than all competitive units.

For the ultimate in filtration and degassing of discreet samples and specific
volumes of solvents, LAZAR presents the Chempure Filtration System. Compared
to the Filter-Degasser which is an "in-line" processing units, the Chempure
is ideal for use where specific volumes of sample and/or solvent must be
filtered and degassed.
As with the LAZAR Filter-Degasser, the Chempure system offers maximum
flexibility being available with various adapter caps for direct use with
1 liter solvent reservoir bottles, 1 gallon solvent bottles, Erlenmeyer flasks
in the range of 125 to 1000 ml which have the 24/40 glass joint or the 40/35
glass joint Millipore®  type flask. Chempure funnel volume is 150 ml and this
can be increased to 300 ml with the use of an all fluoropolymer funnel extender. The
Chempure system is useable with most organic and aqueous solvents and samples.


Ordering Information

ITEM				  CATALOG NO.	   DESCRIPTION
Chempure Filtration System	   CP-256	    with 38 mm cap.
	  "    		           CP-256-33	    with 33 mm cap.
	  "			   CP-256-28	    with 28 mm cap.
	  "			   CP-256-24	    with 24/40 std. taper.
	  "		           CP-256-22	    with 19/22 std. taper.
	  "			   CP-256-35	    with 40/35 std. taper.
	  "			   A-256	    PFA fluoropolymer funnel extender

Filter Membranes		   SM-256C	   PFA fluoropolymer Filter mem-
(47 mm dia., 0.2 micrometer			    branes for organic sol-
porosity)					    vents, pkg of 10.

Filter Membranes		   SM-256CA	    Hydrophillic filter mem-
(47 mm dia., 0.45 micrometer			    branes for aqueous sol-
porosity)					    vents, pkg of 10.

Vacuum Filtration Manifold System  VFM-266	    with 3 Filter-Degassers
	     "		           VFM-266C	    with 3 chempures
	     "		           VFM-266N	    without filtration units


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Solvent Storage Systems and Dispensing Accessories



 Solvent Bottle Cap Assemblies 
 Total Systems Concept for Isoratic and Grandient Requirments



SOLVENT BOTTLE CAP ASSEMBLIES
Open solvent reservoir bottles or bottles with makeshift caps can lead to
particle contamination and absorption of gasses during the storage and
dispensing of solvent which has previously been filtered and degassed.
LAZAR offers two unique bottle cap assemblies which can minimize solvent
recontamination and gas absorption. These assemblies fit the standard 1 liter
solvent bottle (38mm caps) or 500 and 250ml bottle (28 and 33mm caps).
Adapter cap assemblies are also available for Erlenmeyer flasks with 24/40
standard taper. For users of the Millipore®  type glass filtration apparatus,
LAZAR offers a filter reservoir cap (40/35 standard taper) which fits directly
onto the Millipore® type filtration flasks. This flask now becomes the solvent
reservoir eliminating solvent repouring and the risk of recontamination and
aeration.


 Filter Reservoir Caps (FRC)
 Dispenser Reservoir Caps (DRC)
 LAZAR PFA fluoropolymer Solvent Reservoir (TSR)




FILTER RESERVOIR CAP (FRC)
  
The FRC is a solvent reservoir cap with 1/8 fluoropolymer tubing which attaches
directly onto the HPLC pump. An air vent with disposable membrane filter for
minimizing air contamination and solvent evaporation is included.

ORDERING INFORMATION

ITEM				    CATALOG NO.		DESCRIPTION

Filter Reservoir Cap		      FRC-1		cap, 38mm.
	"			      FRC-2		cap, 33mm.
	"			      FRC-3		cap, 28mm.
	"			      FRC-4		cap, 24/40 std. taper.
	"			      FRC-5		cap, 40/35 std. taper.


DISPENSER RESERVOIR CAP (DRC)
The second type cap assembly available,  the Dispenser Reservoir Cap (DRC),
also minimizes solvent contamination by permitting direct transfer of solvent
via a vacuum siphon without repouring or air exposure. An on/off switching
valve on the cap assembly alllows the pump to be turned off during vacuum
transfer. The use of vacuum minimizes reabsorption of atmospheric gasses.

ORDERING INFORMATION

ITEM				    CATALOG NO.		DESCRIPTION
Dispenser Reservoir Cap		      DRC-1		cap, 38mm.
	"			      DRC-2		cap, 33mm.
	"			      DRC-3		cap, 28mm.
	"			      DRC-4		cap, 24/40 std. taper.
	"			      DRC-5		cap, 40/35 std. taper


LAZAR fluoropolymer SOLVENT RESERVOIR (TSR)
With a total concern for laboratory safety as well as avoidance of possible
contamination problems, LAZAR presents our innovative all fluoropolymer Solvent
reservoir bottle. Manufactured from thick wall fluoropolymer, the TSR eliminates the
possibility of implosions during a vacuum process.
The total inertness of PFA fluoropolymer to almost all organic solvents as well as
aqueous solvents eliminates contamination problems such as alkali leaching
from glass and subsequent pH change in solvents. As a final benefit of the
TSR, the thick, opaque walls of the reservoir protect photosensitive solvents
from the effects of extraneous radiation. As with the solvent bottle cap
above, the fluoropolymer Solvent bottles come with either a filtered air vent or
 fluoropolymer siphon for vacuum solvent transfer directly to the solvent bottle.

ORDERING INFORMATION

ITEM				    CATALOG NO.		DESCRIPTION
PFA fluoropolymer Solvent Reservoir
    with air vent		      TSV-1		1 liter
	"			      TSV-2		500ml.
	"			      TSV-3		250ml.
PFA fluoropolymer Solvent Reservoir
    with siphon			      TSS-1		1 liter
	"			      TSS-2		500ml.
	"			      TSS-3		250ml.



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TOTAL SYSTEMS CONCEPT FOR ISOCRATIC AND GRADIENT REQUIREMENTS
   
For the HPLC user who wants the ultimate in convenience, simplicity,
contaminant free and degassed solvents, LAZAR offers the all fluoropolymer Solvent
Reservoir Systems for isocratic, binary, and ternary work. For ISOCRATIC work,
a Filter-Degasser unit is mounted on top of the 0.25, 0.50, or 1 liter size
 fluoropolymer solvent bottle. The solvent is simutaneously filtered and degassed as
it enters the fluoropolymer bottle. The solvent is stored in the fluoropolymer reservoir and
is delivered to the pump via 1/8 TFE tubing with ¼-28 end fittings.
Particle contamination and reabsorption of environmental gasses is minimized
due to the complete closure of the system. The above system can be fitted with
a Chempure filtration unit to achieve the same results with discrete solvent
volumes. For the HPLC user who is doing binary or ternary GRADIENT work,
LAZAR offers the total solvent reservoir system. This system consists of 2
or 3 fluoropolymer solvent bottles, retrofitted with Filter-Degassers, and a system
console featuring a selector switch for the simultaneous filtering, degassing,
and filling of any of the individual solvent reservoirs. This selector switch
allows vacuum to be activated to the appropriate solvent bottle as the dip
tube is dipped into fresh solvent. After the filling operation is complete, a
second lever is pulled relieving vacuum and applying an inert helium blanket
to the solvent bottle. This system offers the ultimate in purification and
dispensing of multiple solvents while offering the user a pure and simple way
to handle solvents.
The front panel of the system console also provides three ¼-28 standard
receptacles for plumbling directly to the HPLC pump.  The system console can
be purchased separately for use with glass or other types of solvent bottles.

ORDERING INFORMATION
ITEM			       CATALOG NO.	  DESCRIPTION

fluoropolymer Reservoir Isocratic	S-286		   1 liter with Filter-Degasser
	  "			S-286-50	   500ml with Filter-Degasser
	  "			S-286-25	   250ml with Filter-Degasser
	  "   			S-286CP		   1 liter with Chempure Filter
	  "			S-286CP-50	   500ml with Chempure Filter
	  "			S-286CP-25	   250ml with Chempure Filter

fluoropolymer reservoir System         SB-286	      2 one liter fluoropolymer bottles with
	binary				    filter-Degassers and system console
	  "			SB-286CP      2 one liter fluoropolymer bottles with
					    Chempure funnels and system console

fluoropolymer Reservoir System 	ST-286	      3 one liter fluoropolymer bottles with
       ternary				    Filter-Degassers and system console
	  "			ST-286CP      3 one liter fluoropolymer bottles with Chem-
					    pure funnels and system console.

System Console		SC-286		      System console without fluoropolymer
					      bottles.

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