New Medical Tool: Lazar Micro Chloride Electrode Used For
Cystic Fibrosis Screening
Analysis of sweat chloride is routinely used as an indicator
of cystic fibrosis (CF). Elevated sweat chloride
concentrations (greater than 60 mmol/l) are almost exclusively
observed inpatients with the CF defect. In view of the limited
amount of sweat available from infants and the emotional
distress associated with a positive reading, a simple reliable
and reproducible microanalysis technique is needed.
The Lazar ISM-146 Micro Chloride electrode was tested against
standard clinical techniques by the University of Alabama,
pharmacology department, in order to assess its suitability
for routine testing of sweat chloride concentrations.
Infant sweat collected following pilocarpine iontophoresis was
used to compare the chloride concentrations measured
titrimetrically and by HPLC against the values measured by the
Lazar Microelectrode. There was excellent correlation between
the standard clinical methods and the Lazar micro chloride
No false positive results were reported in 55 patients whose
sweat chloride concentrations ranged from 7-43 mmol/l and no
false negative values were reported from 6 patients with
elevated sweat chloride concentrations (60-124 mmol/l).
The results indicated that the new Lazar micro chloride
electrode offers a simple, sensitive and reliable method for
sweat chloride screening and avoids pipeting errors or errors
due to colorometric titrations, which can occur with the
standard clinical methods.
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