New Medical Tool: Lazar Micro Chloride Electrode Used For Cystic Fibrosis Screening
Analysis of sweat chloride is routinely used as an indicator of cystic fibrosis (CF). Elevated sweat chloride concentrations (greater than 60 mmol/l) are almost exclusively observed inpatients with the CF defect. In view of the limited amount of sweat available from infants and the emotional distress associated with a positive reading, a simple reliable and reproducible microanalysis technique is needed. The Lazar ISM-146 Micro Chloride electrode was tested against standard clinical techniques by the University of Alabama, pharmacology department, in order to assess its suitability for routine testing of sweat chloride concentrations. Infant sweat collected following pilocarpine iontophoresis was used to compare the chloride concentrations measured titrimetrically and by HPLC against the values measured by the Lazar Microelectrode. There was excellent correlation between the standard clinical methods and the Lazar micro chloride electrode (r=0.97). No false positive results were reported in 55 patients whose sweat chloride concentrations ranged from 7-43 mmol/l and no false negative values were reported from 6 patients with elevated sweat chloride concentrations (60-124 mmol/l). The results indicated that the new Lazar micro chloride electrode offers a simple, sensitive and reliable method for sweat chloride screening and avoids pipeting errors or errors due to colorometric titrations, which can occur with the standard clinical methods.

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